Dr. A. Murat Eren (Meren)
University of Chicago
A. Murat Eren (Meren) is a computer scientist and microbial ecologist who studies microbial lifestyles in a wide range of habitats that span from oceans and the human gut to sewage infrastructures and insect ovaries. Positioned at the unique intersection between computer science and microbiology, Meren and his group (https://merenlab.org) combine state-of-the-art computational strategies and molecular approaches to shed light on the ecology and evolution of naturally occurring microbial populations, with the primary aim of understanding strategies by which microbes thrive within their ever-changing environments. With their commitment to making science open and accessible, the members of the group are among the most active developers of anvi’o, an open-source software platform that strives to empower microbiologists by providing analytical tools and visualization strategies that aid in comprehending the avalanche of new data that is reshaping microbiology.
Dr. Andi Pauli
Research Insitute of Molecular Pathology
Andrea Pauli (Andi) studied biochemistry in Regensburg, Germany, and obtained her Masters in Molecular and Cellular Biology from Heidelberg University, Germany. In 2004, she started her PhD at the Research Institute of Molecular Pathology (IMP) in Vienna, Austria, co-supervised by Kim Nasmyth and Barry Dickson to investigate non-mitotic functions of cohesin using Drosophila as a model organism. In 2006, she moved with Kim Nasmyth to Oxford University, UK, where she obtained her PhD in 2009, providing the first direct evidence that cohesin has essential functions in post-mitotic cells. As a postdoc in Alex Schier's lab at Harvard University, USA, Andi made two key findings that have shaped her research since: first, translation is widespread outside of protein-coding regions in vertebrates; and second, some of the newly discovered translated regions encode functionally important short proteins, one of which is Toddler, an essential signal for mesodermal cell migration during gastrulation. In 2015, Andi established her own lab at the IMP in Vienna, Austria, with a current focus on (1) the mechanism of vertebrate fertilization and (2) translational regulation during the egg-to-embryo transition. The long-term vision of the Pauli lab is to unravel new concepts and molecular mechanisms governing this fascinating developmental transition that marks the beginning of life. Andi's work has been funded by EMBO, HFSP, the NIH grant to independence (K99), the FWF START Prize, and a Whitman Center Fellowship from the Marine Biological Labs. In 2018, Andi became an EMBO Young Investigator (EMBO YIP), and in 2021 she was elected as an EMBO Member.
Prof. Christoph Bock
CeMM Research Center for Molecular Medicine
Christoph Bock is a Principal Investigator at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and Professor of [Bio]Medical Informatics at the Medical University of Vienna. His research combines experimental biology (high-throughput sequencing, epigenetics, CRISPR screening, synthetic biology) with computational methods (bioinformatics, machine learning, artificial intelligence) – for cancer, immunology, and precision medicine. Before coming to Vienna, he was a postdoc at the Broad Institute of MIT and Harvard (2008-2011) and a PhD student at the Max Planck Institute for Informatics (2004-2008). Christoph Bock is also scientific coordinator of the Biomedical Sequencing Facility of CeMM and MedUni Vienna, informatics group leader at the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (LBI-RUD), coordinator of an EU Horizon 2020 project that contributes single-cell sequencing of human organoids to the Human Cell Atlas, fellow of the European Lab for Learning and Intelligent Systems (ELLIS), and elected member of the Young Academy of the Austrian Academy of Sciences. He has received important research awards, including the Otto Hahn Medal of the Max Planck Society (2009), an ERC Starting Grant (2016-2021), an ERC Consolidator Grant (2021-2026), and the Overton Prize of the International Society for Computational Biology (2017).
Dr. Florian Schmidt
Florian Schmidt is a postdoctoral fellow in the Platt group at the Department of Biosystems Science and Engineering (D-BSSE) at ETH Zurich. Florian obtained his B.Sc. and M.Sc. at the Ruprecht Karl University of Heidelberg where he entered the field of biology winning the 2013 iGEM competition together with fellow students as well as working on CRISPR/AAV gene therapy in the group of Dirk Grimm. During a short stint in the laboratory of Feng Zhang at the Broad Institute of MIT and Harvard, he helped to develop the first AAV-based CRISPR screening library delivered to a living mouse. Together with Randall Platt he then transitioned from Boston to Prof. Platt’s newly founded Laboratory for Biological Engineering at ETH Zurich where he pursued his predoctoral studies and established living microbial diagnostics based on the Record-seq technology he will present during this talk.
Dr. Jan Brugues
Max Planck Institute of Molecular Cell Biology and Genetics
Jan Brugués is a jointly appointed Research Group leader at the MPI of Molecular Cell Biology and Genetics and the MPI for the Physics of Complex systems in Dresden since 2013. His lab works at the interphase between soft matter physics, cell biology, and theory to uncover the principles of how cellular compartments emerge from the interaction of individual molecules. Before starting his research group, he was trained as a theoretical physicist during his PhD jointly between ESPCI Paris (France) and University of Barcelona (Spain). As an HFSP at Harvard University, he investigated how mitotic spindles self-organize from local microtubule interactions despite their high turnover. In his lab, they complement quantitative measurements in vivo with reconstitution approaches to rebuild cellular functions using cell extracts and purified components. They combine these approaches with the development of new quantitative biophysical methods and theory. The goal of the Brugués lab is not only to understand particular cellular processes, but to identify general principles of protein self-organization to eventually provide the physical basis of how cells work. To achieve this, research in his group is centered around two general questions, both aiming at understanding the emergence of cellular compartmentalization. First, they want to understand how the size and shape of spindles arise from the interplay of mechanics, microtubule nucleation, and motor activities, and how these properties change during early development. Second, they want to understand the principles that govern chromatin organization in the nucleus, a question that has been largely ignored from the physical point of view. Both research directions synergize and benefit from their strong expertise in theory, quantitative microscopy, biophysical approaches, and reconstitution.
Dr. Jennifer Gardy
Bill & Melinda Gates Foundation
Dr. Jennifer Gardy joined the Bill & Melinda Gates Foundation’s Malaria team as Deputy Director, Surveillance, Data, and Epidemiology in February 2019. Before that, she spent ten years at the BC Centre for Disease Control and the University of British Columbia’s School of Population and Public Health, where she held the Canada Research Chair in Public Health Genomics. Her research focused on the use of genomics as a tool to understand pathogen transmission, and incorporated techniques drawn from genomics, bioinformatics, modelling, information visualization, and the social sciences. In 2018, Jennifer was named one of BC’s Most Influential Women in STEM by BC Business Magazine and was named one of the Government of Canada’s 20 Women of Impact in STEM. In addition to her science work, Jennifer is also an award-winning science communicator, hosting many episodes of science documentary television, including The Nature of Things and Daily Planet, as well as authoring science books for children, including a new book to be released in 2021.
Dr. Lynn Rothschild
NASA Ames Research Center
Lynn Rothschild, a research scientist at NASA Ames and Adjunct Professor at Brown University, is passionate about the origin and evolution of life on Earth and elsewhere, while at the same time pioneering the use of synthetic biology to enable space exploration. Her research focuses on how life, particularly microbes, has evolved in the context of the physical environment, both here and potentially elsewhere. She has brought her imagination and creativity to the burgeoning field of synthetic biology, articulating a vision for the future of synthetic biology as an enabling technology for NASA’s missions, including human space exploration and astrobiology. Since 2011 she has served as the faculty advisor of the Stanford-Brown iGEM team. Her lab is testing these plans in space on in the PowerCell secondary payload on the DLR EuCROPIS satellite. A past-president of the Society of Protozoologists, she is a fellow of the Linnean Society of London, The California Academy of Sciences and the Explorer’s Club. She was awarded the Isaac Asimov Award from the American Humanist Association, and the Horace Mann Award from Brown University. She has been a NASA Innovative Advanced Concepts (NIAC) fellow four times. Lynn was formerly Professor (Adjunct) at Stanford where she taught “Astrobiology and Space Exploration” for a decade.
Dr. Marie Manceau
College de France
Marie is interested in studying the formation and evolution of patterns in the skin. She completed her PhD in avian developmental biology in the laboratory of Pr. Marcelle at the University of Marseille (France) in 2007, and then moved as a postdoc in the laboratory of Dr. Hoekstra at Harvard University, where she studied the developmental bases of color pattern variation in rodents. Since 2013, she is a Young Research Group Leader at the College de France (CIRB). She also works a few weeks a year as a naturalist guide in the Arctic and Antarctica.
Prof. Matthias Lutolf
École polytechnique fédérale de Lausanne (EPFL)
Professor Matthias Lutolf is Director of the Laboratory of Stem Cell Bioengineering at École polytechnique fédérale de Lausanne (EPFL), Switzerland. His highly innovative and cross-disciplinary research program is focused on the development of bio- and tissue-engineering strategies for improving organoid culture and enabling its translation to real-life applications.
Dr. Michael Levin
Michael Levin’s original background was in computer science and software engineering, and he worked in artificial intelligence and scientific computing. He received his PhD in molecular genetics from Harvard, uncovering the genetic pathway underlying invariant left-right asymmetry of vertebrate embryogenesis. He did post-doctoral work at Harvard Medical School identifying long-range physiological communication upstream of the laterality transcriptional cascade. He started his independent lab at Forsyth Institute in 2000, developing the first molecular tools for probing endogenous bioelectrical signaling in embryogenesis. In 2009, he moved his lab to Tufts University, and in 2016 became the director of the new Allen Discovery Center at Tufts University. His group works at the interface between developmental biology, cognitive science, and computer science. Using biophysics, computational modeling, and molecular genetics, the Levin lab investigates the information processing in tissues that enables cells to cooperate towards the self-assembly and repair of complex anatomies. Developing mathematical models and novel ion channel modulation strategies, they work to understand how all cell types, not just neurons, form electrical networks that make decisions about growth and form. Applications have included reprogramming organ identity, inducing regeneration of appendages, normalizing tumors, and repairing of brain and craniofacial birth defects. By re-writing the bioelectrical “pattern memories” in tissues, they seek to develop applications for regenerative medicine, birth defects, cancer, and synthetic morphology.
Dr. Richard Wombacher
Institute of Pharmacy and Molecular Biotechnology, Heidelberg
Richard Wombacher is group leader at the Chemical Biology Department of the Max-Planck-Institute for Medical Research in Heidelberg. Richard graduated in chemistry at the Free University of Berlin and received his Ph.D. at the Ruprecht-Karls University working in the field of RNA catalysis. After a post-doc with Virginia Cornish at the Columbia University in New York, he started his own research group at the Ruprecht-Karls University, working in in the field of chemical biology and protein chemistry. In 2020 Richard became group leader at the MPI for Medical Research in Heidelberg. The research of his group is focused on the development and application of chemical tools for control of protein function and modification. This includes biorthogonal chemistry, probe development for advanced imaging technologies like super-resolution microscopy and single molecule microscopy as well as optochemicals for protein manipulation with high spatiotemporal control.
Dr. Sara-Jane Dunn
Dr Dunn is a Research Scientist at DeepMind. She has a Masters in Mathematics from the University of Oxford, where she also achieved her doctorate in Computational Biology. Prior to DeepMind she was a Principal Scientist at Microsoft Research, having joined as a Postdoctoral Researcher in 2012. She is an Affiliate PI of the Wellcome-MRC Stem Cell Institute, University of Cambridge. Her research interests are in the domain of biological computation: how we can uncover the fundamental principles of biological information-processing, and use this understanding to tackle important, impactful problems in the field.
Prof. Sarah Heilshorn
Heilshorn's interests include biomaterials in regenerative medicine, engineered proteins with novel assembly properties, microfluidics and photolithography of proteins, and synthesis of materials to influence stem cell differentiation. Current projects include tissue engineering for spinal cord and blood vessel regeneration, designing injectable materials for use in stem cell therapies, and the design of microfluidic devices to study the directed migration of cells (i.e., chemotaxis).
Dr. Simon Haas
Heidelberg Institute For Stem Cell Technology And Experimental Medicine
As of 2020, Simon Haas is an independent group leader at the Berlin Institute of Health (BIH), the Charité university medicine and the Berlin Institute of Medical Systems Biology (BIMSB) at the Max Delbrück Center (MDC) in Berlin, Germany. He is also an associated group leader at the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany. Simon studied Molecular Cell Biology, Biochemistry and Molecular Biosciences at Heidelberg University, Imperial College London and the DKFZ. He received his PhD from DKFZ and Heidelberg University in 2016 (with Marieke Essers). Simon performed research at DKFZ, Massachusetts Institute of Technology (MIT) and Harvard. Since 2016, he is a junior group leader at HI-STEM (with Andreas Trumpp). His research focus is to understand the blood and immune system, and how it contributes to disease, in particular cancer. For this purpose, his lab develops single-cell transcriptomic, genomic, surface proteomic, functional and spatial technologies, and combines those with classical approaches from the fields of immunology, stem cell biology and cancer. As part of the hematology, oncology and tumor immunology departments of Europe’s largest university hospital at the Charité and core member of the BIH / MDC focus area ‘Single-Cell Approaches for Personalized Medicine’ one of his main goals is to transform single-cell technologies into precision oncology approaches that provide ultra-precise diagnostics, prognostics and guide therapy choice in cancer therapy.
Dr. Smita Shankar
Smita Shankar is the VP of Biomanufacturing at Impossible Foods. She leads the team responsible for manufacturing and scaling Impossible Burger’s “magic” ingredient – soy leghemoglobin, or “heme” – which provides the unmistakable flavor and aroma of meat. Previously, Smita was the VP of R&D at Impossible. Smita joined Impossible Foods in 2013 as one of the company’s first R&D hires. Following Impossible’s discovery of heme as a key ingredient in 2014, she built the company’s microbial strain development program from scratch, leading to industrial-scale production of recombinant proteins. Over the next seven years, Smita oversaw the implementation of new research and technology, built multiple production plants, and established a world class team of scientists and engineers. In 2017, her work resulted in a mission-critical patent covering Impossible Foods’ unique method of producing heme at scale. Prior to Impossible Foods, Smita worked at Codexis engineering microbes to make sustainable bio-based detergent alcohols.Smita got her Ph.D. in Biochemistry, Molecular and Cellular Biology at Cornell University, where she studied bacterial gene expression. Following her Ph.D. she was a postdoctoral fellow at the University of California, San Francisco, where she researched the genetic manipulation of yeast through a fellowship from the Leukemia and Lymphoma Society.
Dr. Suliana Manley
Ecole polytechnique federale de Lausanne
Born in the United States, Suliana Manley studied at Rice University where she obtained a bachelor's degree in physics and mathematics in 1997, cum laude. She continued her studies at Harvard University, where she earned a PhD in physics under the supervision of Prof. Dave Weitz in 2004. After this, she conducted postdoctoral research on lipid bilayer and red blood cell membrane dynamics at MIT. She subsequently went on to work as a postdoctoral researcher in the cell biology laboratory of Jennifer Lippincott-Schwartz at the National Institutes of Health (USA). During this time, she developed a highly promising optical method (sptPALM) for studying the dynamics of large ensembles of single proteins in membranes and inside cells. Currently, at the Ecole polytechnique federale de Lausanne, her lab develops and utilizes automated super-resolution fluorescence imaging techniques combined with live cell imaging and single molecule tracking to determine how the dynamics of protein assembly are coordinated.
Dr. Valentina Greco
Yale School of Medicine
Valentina Greco, PhD, is the Carolyn Walch Slayman Professor of Genetics at Yale University. She studied Molecular Biology at the University of Palermo (Italy), and later pursued her PhD at EMBL/MPI-CBG. After a postdoc at the Rockefeller University (USA), she joined the Yale Stem Cell Center, the Yale Cancer Center, and the Genetics, Cell Biology, and Dermatology Departments at Yale University, where she opened her lab. The Greco lab aims to define how tissues maintain themselves throughout our lives in the face of continuous cellular turnover, frequent injuries and spontaneous mutations. The lab also operates at the forefront of technological innovation, having established multiple approaches to visualize and manipulate stem cells in intact animals. During the course of her career, Dr. Greco has been honoured with several awards, including most recently the 2021 International Society for Stem Cell Research (ISSCR) Momentum Award, the 2019 NIH Director’s Pioneer Award, the 2019 Yale Postdoctoral Mentoring Award, the 2018 Yale Graduate Mentor Award in the Natural Sciences, and in 2018 she was named the Inaugural Holder of the Carolyn Slayman Endowed Professorship.